Construction safety is the lifeline of water transportation engineering construction.Because of the particularity of professional span,environmental impact and operation risk,the safety management of navigation-power junction project is facing great pressure and challenge.In this paper,the working contents,difficulties and key points of safety management in the construction of navigation-power junction project are deeply studied,and specific control methods and measures are put forward from overall safety management,risk source management,personnel quality improvement,overcoming safety science and technology difficulties,and safety intelligent control,which achieves good safety control effect in the construction site.The research results can provide the reference for the safety management of similar projects.