China-Maldives Friendship Bridge adopts a pile group foundation, and vertical and horizontal displacements appear when the ocean current passes the pile group. In order to explore the calculation method of the flow load of the isomerism pile group, this paper measures the flow load of single and double piles by a one-way tank model test, proposes a formula for the flow load of the isomerism pile group, and verifies the rationality of the formula according to the test results of flow load of pile group. The results show that the flow load of the parallel two piles decreases with the increase in the pile center distance, and the interference effect between the two piles disappears when the pile center distance is greater than 5D. In addition, the flow load of the back pile of two piles in series increases with the increase in the pile center distance, and the shielding effect between the two piles weakens when the pile center distance is greater than 20D. With the increase in the angle of current, the flow load of the back pile presents a sinusoidal distribution, and different trends appear with the change of pile center distance.