Based on MIKE 21 Mooring Analysis software，we study the motion of moored ships subjected to irregular waves with different periods and incident angles. The results show that the variations of motion of the moored ship interact with each other for different wave incident angles and periods. Sway，roll and heave motions of the moored ship increase with the increase of the wave incident angle，and the effect of the roll resonance decreases with the wave incident angle away from the direction of 90°，the heave motion change little when the wave incident angle is close to the direction of 90°or 0°. When the incident wave period is long，the surge motion and yaw motion first increase and then decrease with the increase of the wave incident angle，and generally have a peak value when the wave incident angle is 60°.