This paper introduces the general layout of the port for PLTU 2 JAWA BARAT PALABUHANRATU 3×350 MW in Indonesia, analyzes major natural factors affecting the general layout: wind, wave, sediment, current, tide and geology, etc., and discusses key technical issues about the general layout. According to the characteristics of the project, three types of the general layout scheme are proposed. The recommended scheme is based on the comprehensive comparison after studies of the wave physical model, cooling water draining model and sediment movement.