Cone penetration test with pore pressure measurement (CPTU) is a rapid in-situ test method. Most interpretation methods are based on empirical correlations through statistical analysis at present. Based on the wide application of CPTU data interpretation on soil classification, undrained shear strength of cohesive soil, friction angle of sandy soil and subgrade uniformity to the soil investigation of Hong Kong-Zhuhai-Macau bridge, some conclusions are drawn.