Based on the investigation of the crack on lock’s concrete structure built and under construction, this paper analyzes the cause of the crack combining the engineering practice of Shiqiao third line ship lock. It puts forward a more comprehensive technology on prevention and control of the concrete crack, such as the optimization of concrete mix ratio based on the simulation analysis of anti-shrinkage and crack resistance of concrete; use of the liner templates in dehydration construction technology to improve the surface’s crack resistance; polystyrene external thermal insulation technology; optimization of structural design, as well as improvement of boundary constraint conditions. The integrated application of crack prevention and control may serve as reference for the scientific research, design, supervision and construction.