Guniusha waterway, which is located in the middle Yangtze River, is composed of the restrictive bend and straight segments which are under the control of the double nodes, and has always been maintaining favorable channel conditions. However, in recent years the waterway condition turns adverse and navigation obstruction occurs constantly. Based on the real-measured water and sediment data of Guniusha waterway, this paper analyzes the river bed evolution and navigation obstruction characteristics, reveals the factors which impact the evolution, and proposes corresponding regulation measures, which provides a reference for the engineering practice.