Based on the analysis of the bed ev olution and navigation-obstructing characteristics of Wuxue waterway in the midstream of the Changjiang River, we determine the new regulation idea for the waterway which is coordinated with the sand winning plan of the locality and solve the contradiction between the regulation engineering and san winning based on the river model experiment. Meanwhile, we adjust timely the scheme and staged implementation of engineering based on the principle of dynamic management and according to the topographic variation of the engineering site during construction. After the implementation of the project during 2006 and 2008,the waterway evolution trend was basically the same as the model experiment result, the waterway condition was improved obviously, and the san winning activity was regulated.