To address the constraints of limited space and the complex construction and operational environment at Huai’an East Ship Lock,the study on its layout is conducted using mathematical and physical modeling.The research comprehensively considered multiple factors,including traffic capacity,the impact on flood and embankment stability of the general channel for irrigation and the Huaihe River estuary waterway,as well as navigation flow conditions.The results show that the upstream separation levee should adopt a uniform porous structure with 67% porosity,while the downstream separation levee requires a gradual transition porous structure with 8%-25% porosity.Moreover,after the width of the upstream entrance area is increased to 112.5 m,the navigation water flow conditions meet the requirements.The main and auxiliary navigation walls adopt an empty box structure and a plastic concrete diaphragm wall anti-seepage structure,which can effectively reduce the occupation of flood discharge area.After dredging 103,000 and 360,000 m3 of flood discharge compensation measures in the upstream and downstream respectively,the impact of ship lock construction on the flood discharge of the main channel and the sea channel can be basically eliminated.The research results can provide reference and guidance for the layout and safe operation of similar ship locks.